This is going to be a short one. Almost short enough to be a Tweet.
Problem: Toughbook hotkeys are not working properly after updating to Windows 10.
Solution: Go to your installed programs (Settings > System > Apps & features) and look to see if Hotkey Appendix and/or Hotkey Settings is installed. If they are, uninstall them. They are not necessary in Windows 10 and are likely causing a conflict.
Problem still not solved? Make sure your video and hotkey drivers are up to date. If that doesn't solve it, leave a comment below and we'll do our best to help.